Philadelphia from the top.
Gas chromatography mass spectrometry as tool for engineered strains.
Isolation of natural products from soil bacteria.
Computational mining for secondary metabolite clusters.
Zone of inhibition of antibacterial compound.
Mass spectrometry guided discovery of novel secondary metabolites, facilitates the discovery of novel compounds, potentially new drugs. Imaging mass spectrometry can visualize the metabolites of microbiomes, in the environment or in the clinic.learn more
Changing the flux of metabolites in an organism allows us to produce high-value molecules in several hosts. The introduction of new enzymes or the deletion of native enzymes, facilitates the production of fuel, plastics, drugs and others, in bacteria.learn more
Bioassay guided discovery of novel secondary metabolites (natural products) from new microbial sources, combined with computational mining of biosynthetic clusters, evoltion-based screening, and mass spectrometry, will lead to new drugs.learn more
Fatty acid supplementation reveals differences in fatty acid metabolism. Published in Molecular Biosystems.
Check out this recent paper on mining genomes.
First undergraduate researchers in the lab!
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